Light therapy can protect the heart
Scientists have discovered that blocking a specific gene could help heart health, but it can also be fatal. New research now shows that bright light can be a way to remove this risk .
The gene, ANGPTL4, is essential for the regulation of plasma lipids and is therefore an attractive therapeutic target for cardiovascular disease. Scientists have found that people with lower levels also have low triglycerides and lipids, which means a lower risk of cardiovascular disease. The gene can also work to reduce the risk of myocardial ischemia and help repair a damaged heart.
Unfortunately, ANGPTL4 blockade results in a proinflammatory and lethal phenotype in animals. The discovery of cardiac ANGPTL4 as a circadian protein reveals a new mechanistic perspective and a solution to this therapeutic dilemma.
Seeking to safely block this gene, scientists at the University of Colorado Anschutz Medical Campus seem to have found a new useful tool – light .
The study, recently published in the journal Trends in Molecular Medicine, could solve a medical dilemma that has puzzled scientists for years.
“The scientific community is still trying to find a way to safely inhibit it,” said the study’s lead author, Tobias Eckle, MD, PhD in Professor of Anesthesia at the University of Colorado School of Medicine. We have now discovered that ANGPTL4 is a gene with a circadian pattern. It can be influenced by light.
Eckle previously discovered that light therapy can protect the heart and that the ANGPTL4 gene was light -dependent. It is believed that the gene could be manipulated by light without risking the lethal effects of blocking it entirely. The gene can be activated by light therapy, a flavonoid known as nobiletin, or by drug formulations.
In fact, circadian amplification of ANGPTL4 amplitude would be quite distinct from deactivation or even overexpression, Eckle said. “At certain times of the day, the ANGPTL4 response would have improved 12 hours later, and the response would have been even more suppressed.” through the human body.
“Sunlight and oxygen are the things that support life on this planet ,” Eckle said. He also said that chronotherapy, the administration of drugs at different times of the day, to maximize benefits and minimize side effects, is a new frontier in medicine.
“The administration of any drug should be linked to a certain time of day,” he said. “I think chronotherapy is the future of medicine.”
And if it’s still the ideal season for walks and outings in nature, a walk of at least 30 minutes a day in sunlight can protect your heart health. Opt for a healthy lifestyle, a balanced diet and outdoor exercise, and your body will be grateful!
And in addition to this classic recipe, for a healthy heart, you can opt for the chronotherapy options available now.
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